Medullary Breast Carcinoma: A Case Report and Review of Literature

Medullary carcinomas both typical (MBC) and atypical (AMBC) are rare breast tumors that account for <5% of invasive breast carcinomas [1]. The diagnosis of medullary carcinoma is usually defined by histologic diagnostic criteria proposed by Ridolfi et al. [2]. These histopathological features include: syncytial growth pattern (>75%), absence of glandular structures, diffuse lympho-plasmacytic infiltrate, grade 2 or 3 nuclei and complete histological circumscription. Atypical MBC differs from typical MBC in terms of patholog ic features with an infiltrative margin, mild mononuclear infil tration, a low nuclear grade, and presence of an intra-ductal component [3].